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Immunological Responses to Implant Biomaterials Following Arthroplasty

By Wooley, Ph.D., Paul H.; Whalen, B.S., Janey D.; Sud, M.Phil., Sudha; Song, B.S., Zheng; Fitzgerald Jr, M.D., Robert H.; Nasser, M.D., Sam; Wayne State University School of Medicine, Detroit, MI; Rehabilitation R & D Progress Reports, 1995, Vol 33
(Pages: 197-198) Publication Date: June 1996

This article describes a study whose aim is to determine if implanted biomaterials elicit an inflammatory immune reaction, which may lead to osteolysis with eventual failure of the prosthesis. Two investigative methods are used: 1) failed prosthetic implants are examined for the presence of antibodies bound to the implant surface, or reactive with proteins bound to the implant; 2) Cellular responses to biomaterials are measured in peripheral blood mononuclear cells (PBMC) from patients with painful or loosened total joint prostheses.
Published by: VA Rehabilitation Research & Development Service   (Website:http://www.rehab.research.va.gov)
Link to text: http://www.vard.org/prog/progindx.htm
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